FFMI and MAMC assessment in COPD patients – anthropometry
Apart from decreased lung function, patients with COPD have many systemic complications, such as malnutrition and cachexia, which may lead to development of other comorbidities, e.g., muscle depletion, osteoporosis, diabetes mellitus etc. Muscle loss is considered as a better predictor of mortality than BMI (Rutten et al., 2010).
Fat free mass index (FFMI) and mid arm muscle circumference (MAMC) can be used for the assessment of muscle mass after pre-and post-therapeutic intervention. Muscle loss can be quantified using FFMI as well. Muscle mass is calculated through skinfold caliper measurement, which was shown to be second best to DEXA (Hronek et al., 2013).
Body density is calculated using the Durnin and Womersley equation (Durnin and Womersley, 1974), using the data from skinfold measurement in 4 locations on the body. Fat mass (FM) and fat free mass (FFM) is calculated using the Siri equation (Siri, 1961). FFMI is the proportion of FFM to the height squared in kg/m².
Patient’s muscle reserves and muscle loss can be evaluated by MAMC on the non-dominant side. It is calculated using upper arm circumference and thickness of skinfold above the triceps muscle, both on the non-dominant side of the body (Hronek, 2011).
Table1. Patient condition according to FFMI a BMI
FFMI |
BMI |
|||
< 21 |
21-25 |
25-30 |
> 30 |
|
♂ <16; ♀ <15 |
cachexia |
muscle atrophy |
muscle atrophy |
not possible |
♂ >16; ♀ >15 |
underweight |
normal |
overweight |
obesity |
(Schols, 2009)
Table 2. Muscle loss evaluation according to MAMC
Patient condition | ||||||||
Physiologic | Muscle loss | Significant muscle loss | ||||||
% of standard | 100 | 90 | 80 | 70 | 60 | 50 | 40 | |
MAMC | ♂ | 25,5 | 23,0 | 20,0 | 18,0 | 15,0 | 12,5 | 10,0 |
♀ | 23,0 | 21,0 | 18,5 | 16,0 | 14,0 | 11,5 | 9,0 |
(Hronek et al., 2011)
Doc. PharmDr. Miloslav Hronek, Ph.D.
PharmDr. Miroslav Kovařík, Ph.D.
Charles University, Faculty of Pharmacy and University Hospital in Hradec Králové
References
Durnin JVGA, Womersley J. Body fat assessed from the total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. British Journal of Nutrition, 1974; 32(1): 77-97.
Hronek M, Kovarik M, Aimova P, Koblizek V, Pavlikova L, Salajka F, Zadak Z. Skinfold Anthropometry – The Accurate Method for Fat Free Mass Measurement in COPD. COPD, 2013; 10(5): 597-603. doi:10.3109/15412555.2013.781151
Rutten EP, Spruit MA, Wouters EF. Critical view on diagnosing muscle wasting by single-frequency bio-electrical impedance in COPD. Respiratory Medicine, 2010; 104(1): 91-8.
Schols A. Nutritional Assessment and Support. In: Hodgkin JE, Celli BR, Connors GL (eds.). Pulmonary Rehabilitation, Guidelines to Success 2009.
Siri WE. Body composition from fluid space and density. Brozek J, Hanschel A (eds.). Techniques for measuring body composition (pp. 223-244). Washington, DC: National Academy of Science. 1961.